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It is believed that the civilization was later devastated by the spread of diseases from Europe, such as smallpox.

Among those were evidence of roads, bridges and large plazas.

Analyses of sediment deposits from Amazon basin paleolakes and from the Amazon Fan indicate that rainfall in the basin during the LGM was lower than for the present, and this was almost certainly associated with reduced moist tropical vegetation cover in the basin.

This debate has proved difficult to resolve because the practical limitations of working in the rainforest mean that data sampling is biased away from the center of the Amazon basin, and both explanations are reasonably well supported by the available data.

Water on the eastern side flowed toward the Atlantic, while to the west water flowed toward the Pacific across the Amazonas Basin.